I Wish I Were Far From the Madding Crowd

April 11, 2010

Some Breast Cancer Cases Caused by a Virus?

It looks like the answer could very well be yes.

The Pink Virus Project

See Dr. Ruddy’s latest post describing her long history in this area.

“Breakthroughs Around the Globe”

Approximately 40% of human breast cancers contain gene sequences that are remarkably similar to a retrovirus known to cause breast cancer in domestic mice. Furthermore, the highest incidence of human breast cancer worldwide occurs in geographic locations where the domestic mouse is native or introduced to the area.

The book, The Pink Virus: Does a Virus Cause Breast Cancer in Women?

Presentation by Dr. Ruddy on The Pink Virus

Summary of Research

http://breastcancerbydrruddy.com/2009/11/01/the-pink-virus-2/

Brief Report on the Pink Virus Breast Cancer Summit

http://www.breasthealthandhealing.com/socialnetworking/messages/20091101.html

Cancer-Causing Virus Linked to Breast Cancer – Includes more info on the Pink Virus Project summit.

Brief bibliography on breast cancer and viruses

Articles cited at bottom of page at http://www.breasthealthandhealing.com/socialnetworking/messages/20091001.html

Updated (and more technical) Bibliography of Research on the Mammary Tumor Virus

http://breastcancerbydrruddy.com/2009/11/15/updated-bibliography-of-research-on-the-mammary-tumor-virus/

Breast Health and Healing’s YouTube Channelhttp://www.youtube.com/user/BreastHealthHealing

A New Virus in a Spontaneous Mammary Tumor of a Rhesus Monkey. Harish C. Chopra and Marcus M. Mason.  Cancer Research 30, 2081-2086, August 1, 1970. http://cancerres.aacrjournals.org/cgi/content/abstract/30/8/2081

Chemical Exposure and Breast Cancer?

The CDC has reported in its Fourth National Report on Human Exposure to Environmental Chemicals that many chemicals are showing up in Americans’ bodies.  (Presence alone does not indicate adverse effects, but as I have blogged about before, exposure during certain windows of development can have long-term effects.)

The Fourth Report includes results for 75 chemicals measured for the first time in the U.S. population.  Among the chemicals: environmental phenols, including bisphenol A and triclosan.  According to the Executive Summary:

  • Bisphenol A (BPA), a component of epoxy resins and polycarbonates, may have potential reproductive toxicity. General population exposure to BPA may occur through ingestion of foods in contact with  BPA-containing materials. CDC scientists found bisphenol A in more than 90% of the urine samples representative of the U.S.population.
  • Polybrominated diphenyl ethers are fire retardants used in certain manufactured products. PBDEs accumulate in the environment and in human fat tissue. One type of polybrominated diphenyl ether,BDE-47, was found in the serum of nearly all of the NHANES participants.

Could women be more vulnerable to a breast cancer virus because of exposure to environmental chemicals (either because the chemicals themselves might contribute, or because they negatively affect the immune system)?  See recent articles at bottom about BPA and phthalates.  See also U.S. News post re what could possibly be one of the more likely sources of BPA exposure—your receipts, not plastic bottles. (Science News itemWarner Babcock Institute for Green Chemistry)

Articles Ahead of Print from Environmental Health Perspectives

Bisphenol A (BPA)

“Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus.” – Online April 9, 2010.

Nishikawa M, Iwano H, Yanagisawa R, Koike N, Inoue H, Yokota H 2010. Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus. Environ Health Perspect :-. doi:10.1289/ehp.0901575

Urinary, Circulating and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Laura N. Vandenberg, Ibrahim Chauhoud, Jerrold J. Heindel, Vasantha Padmanabhan, Francisco J.R. Paumgartten, Gilbert Schoenfelder Online 24 Mar 2010 | doi:10.1289/ehp.0901716

Phthalates

Investigation of Relationships between Urinary Biomarkers of Phytoestrogens, Phthalates, and Phenols and Pubertal Stages in Girls

Mary S. Wolff, Susan L. Teitelbaum, Susan M. Pinney, Gayle Windham, Laura Liao, Frank Biro, Lawrence H. Kushi, Chris Erdmann, Robert A. Hiatt, Michael E. Rybak, Antonia M. Calafat Online 22 Mar 2010 | doi:10.1289/ehp.0901690

Articles notes a weak association between exposure and earlier puberty.  In a press release Dr. Wolff noted that though the association is weak, given the widespread exposure the public health implications are actually quite large.

This was a multi-ethnic longitudinal study of 1151 girls from New York City, greater Cincinnati, and northern California who were 6-8 years old at enrollment (2004-2007).  Measurements were done one year later.

Results: Breast development was present in 30% of girls (ed. note: remember the girls would have been 7-9), and 22% had pubic hair. High-molecular-weight phthalate metabolites were weakly associated with pubic hair development (adjusted PR 0.94 (0.88-1.00), fifth vs first quintile). Small inverse associations were seen for daidzein with breast stage and for triclosan and high-molecular-weight phthalates with pubic hair stage; a positive trend was observed for low-molecular-weight phthalate biomarkers with breast and pubic hair development. Enterolactone attenuated BMI associations with breast development; in the first enterolactone quintile the association of high-BMI with any development was 1.34 (PR, CI 1.23-1.45 versus low-BMI); there was no BMI-association in the fifth, highest quintile of enterolactone.

Conclusions: Weak hormonally active xenobiotic agents investigated in this study had small associations with pubertal development, mainly among those agents detected at highest concentrations.

My point?  There are enough risks for breast cancer from other causes that we do not need to be assaulted by chemicals in our environment.

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2 Comments

  1. Thank you for sharing this important information on your website and for helping to create the tipping point that will result in a grassroots demand for more research on the human mammary tumor virus.

    Comment by DrKTRuddy — April 11, 2010 @ 3:47 pm

  2. This is fascinating research! This should be taken seriously by women who are concerned with their health. The ONLY true cure is finding the cause, which can end this disease once and for all.

    I suggest you ladies download the Pink Virus book and pick it for your next book club read! It’s a great way to get your friends involved and begin asking question such as:

    “Does a virus really cause breast cancer?”

    “Can this cancer truly be prevented in the near future?”

    “How long has this data been around?”

    “Why hasn’t the American public heard this before?”

    “What effect would this have on millions of people?”

    “What can I do to spread the word?”

    Answering these questions at a fun book club meeting would definitely lead to an interesting night of conversation!

    Comment by Maureen — April 11, 2010 @ 10:33 pm


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